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Vacancies at the IBIVU Center
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| ♦ Introduction |
| Background: |
The IBIVU is a recently founded broad-based centre that is
carried by the Faculty of Sciences (FEW)
and the Faculty of Earth and Life Sciences (FALW)
with strong endorsement from the University Board (CvB) and intimate
ties with the VU Medical Centre (VUMC).
Its main missions are carrying out a strong
and internationally competitive research programme in Bioinformatics with an
additional focus on functional genomics and systems biology, and providing an
excellent educational programme at bachelor and master level; the latter including
a two-year international Bioinformatics Master's course.
The Centre is going
through a phase of expansion both in staffing and research projects as a result
of university and grant-based funding.
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| Research Focus: |
In addition to a core research group with a tools-directed focus, the IBIVU is
involved in a number of projects in collaboration with institutes and groups
at the Vrije Universiteit, such as the Institute for Molecular Cell Biology
(IMC),
The Centre for Neurogenomics and Cognitive Research
(CNCR), and the Microarray
facilities at the VU Medical Centre. The IBIVU research is embedded in a number
of externally funded bioinformatics research directions, such as (1) the
Dutch national Ecogenomics
project which focuses on genomics-based soil-ecosystems
research, (2) the Dutch national Centre for Medical Systems Biology
(CMSB),
(3) the Netherlands Bioinformatics Centre's
BioRange project.
An international focus is the IBIVU partnership in the EC FP6 Bioinformatics/Systems
Biology related Network of Excellence
ENFIN.
The IBIVU therefore seeks to extend its
focus on genome-wide discovery-based bioinformatics research with a clear
systems-based and modelling-directed component.
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| ♦ PhD Student Integrative Bioinformatics |
| Position: |
PhD Student (promovendus) Integrative Bioinformatics
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| Title: |
PhD Student Integrative Bioinformatics
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| Project: |
The key objective of the project is to enhance building of biological knowledge by integrating data in a multi-scale integrated fashion, to enable the incorporation of the evolutionary perspective of biological systems. Typically, analysis of multiple sequence alignments and (other) comparative genomics approaches deal directly with this evolutionary perspective, but do not integrate with network-scale data.
A core network technique will be developed to specify connections between query proteins; e.g. corresponding to a metabolic, regulatory, or interaction network. This allows the combination of comparative genomics and parallel iterative homology searching whereby synergy between putative homologues (evolutionary conservation of networks) leads to optimized functional annotation for each of the sequences in the network. For example, if a search is carried out for a set of metabolic pathway-related protein sequences, then if one sequence is recognized in a given genome, the search stringency could be relaxed for metabolic counterparts within that genome. In this way, searching with one query sequence in the network will provide information to the search for another. Or, in other words, the sequence search is made aware of the context (metabolic, evolutionary or otherwise) of the query protein.
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| Requirements: |
Candidates should have an MSc degree in Bioinformatics or a closely related area. Experience with biological systems is essential. Experience with computer science and an open attitude to applications are considered advantages. You should enjoy working in an interdisciplinary and internationally oriented research environment. Communicative skills and the ability to work in a team are important. |
| Contact information: |
For more information please contact:
Prof. Jaap Heringa
IBIVU
e-mail: heringa@cs.vu.nl
tel. +31 (0)20 59 87649
fax. +31 (0)20 59 87653
Full vacancy description
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| ♦ How to apply |
- Send your application (writing the application number at the top left
side of the letter and envelope) before the specified deadline to:
Ms. M. Mabuto-Cohen
Human Resource Officer
Faculty of Sciences
Vrije Universiteit
De Boelelaan 1083-A
1081 HV Amsterdam
The Netherlands
- Alternatively, you can e-mail your application letter to:
FEW-vacatures@few.vu.nl
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