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Scooby-domain prediction

scooby logo

Scooby-domain (Sequence hydrophobicity predicts domains) is a method to identify globular regions in protein sequence that are suitable for structural studies. The current version is 2.0. Note however, that the JAVA applet runs version 1.0. The Scooby-domain JAVA applet (v1.0) can be used as a tool to visually identify 'foldable' regions in protein sequence.


cog WSDL: SOAP interface available.

George RA, Lin K and Heringa J. (2005) Scooby-domain: prediction of globular domains in protein sequence. 2005. Nucleic Acids Research 33: W160-163.

Pang CN, Lin K, Wouters MA, Heringa J, George RA. (2008) Identifying foldable regions in protein sequence from the hydrophobic signal. Nucleic Acids Research 36: 578-588.

Paste in a protein sequence or alignment in fasta format:*

Or Upload a sequence:

Or Supply a UniProt ID:

Include your own linker annotation file:

Use DomCut on first sequence only (recommended)
Use DomCut on all sequences
Do not use DomCut


*Note: allowed gap symbols are "." and "-". Gap symbols in a single sequence will not be deleted.

The ScoobyDo web server was developed by Richard George. Updated & maintained by Bernd Brandt.

(c) IBIVU 2021. If you are experiencing problems with the site, please contact the webmaster.