Sequence Harmony is an entropy-based method, which accurately
detects subfamily specific functional sites from a multiple sequence
alignment. The algorithm implements a new formula, able to score
compositional differences between subfamilies in a simple manner on an
Information on the Input format
More on Method Background
If you use our method, please cite:
Feenstra KA, Pirovano WA, Krab K and Heringa J.
Sequence Harmony: Detecting Functional Specificity from Alignments.
Nucl. Acids Res., 2007, Vol. 35, W495-W498.
Pirovano WA1, Feenstra KA1 and Heringa J.
Sequence Comparison by Sequence Harmony Identifies Subtype Specific
Nucl. Acids Res., 2006, Vol. 34, No. 22 6540-6548.
1 joint first authors