YASPIN is a HNN (Hidden Neural Network) secondary structure prediction program that uses the PSI-BLAST algorithm to produce a PSSM for the input sequence, which it then uses to perform its prediction.
Reference: Lin K., Simossis V.A., Taylor W.R. and Heringa J. (2005) A Simple and Fast Secondary Structure Prediction Algorithm using Hidden Neural Networks. Bioinformatics. 21(2):152-9. Abstract
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