BICEP: Baseline Increase in heat Capacity Estimation with hydroPhobicity


		BICEP: Baseline Increase in heat Capacity Estimation with hydroPhobicity

The BICEP server models the linear increase in heat capacity of native proteins. You can input a protein structure via a PDB identifier or upload a PDB-formatted file and optionally provide experimental data on the heat capacity. The output includes the calculated hydrophic surface area (HSA) and molecular weight as well as the equation for the HSA baseline, and a graph of the heat capacity baseline, optionally including the experimental data. The hydrophobic residues in the structure are coloured in the protein and provided as static images as well as interactively via the Jmol applet.
Requirements:
For optimal use, please enable Javascript. For using the optional Jmol applet, you need to have any new web browser supporting the HTML5 canvas.

Documentation:

Introduction to the BICEP web server in HTML or PDF.

Example output.

You can also rerun the example.
A standalone version is available at Bitbucket.

References:

van Dijk, E., Varilly, P., Knowles, T.P.J., Frenkel, D. and Abeln, S. (2016) Consistent treatment of hydrophobicity in protein lattice models accounts for cold denaturation. Physiscal Review Letters (accepted).

Supply your PDB ID:
Chain:

or upload your PDB file:

Include Freire's baseline

Fix intercept: temperature heat capacity

Upload experimental data (optional):

The BICEP web server was developed by Bernd Brandt.